You’ll find everything you love and more in Sioux Falls during your business or leisure getaway at our Comfort Inn & Suites^® Avera Southwest hotel. Located on the southside of the city, our hotel is just 8 miles from the entrance of the Sioux Falls Regional Airport. We’re also conveniently located off Interstate 29 and Interstate 229, which means you’ll be just minutes from downtown Sioux Falls, the city’s namesake cascades in Falls Park and other memorable attractions here in the “Heart of America.”