Comfort Inn Hotels in South Carolina

From the cobblestone colonial streets to the luxury of the peaceful coastline, history, culture and a limitless dose of Southern charm await in South Carolina. As a guest at any of our South Carolina Comfort Inn hotels, we want to ensure that you find rooms as unique as the Palmetto State — while offering comfortable accommodations at an affordable rate. Stroll the cobblestone streets of Historic Charleston, one of our nation’s first colonial cities, or step into the past at Fort Sumter. Stand beneath live oak trees draped in Spanish Moss, or trek Table Rock in the Blue Ridge Mountains. Sample the delectable dining or soak up sun at Myrtle Beach. Bask in the BBQ at a football tailgate at Clemson or Columbia. We strive to help make your stay Truly Yours at our Comfort Inn South Carolina hotels, whether you’re looking for business or tourist destinations. Enjoy free wireless high-speed Internet, heated swimming pools, fitness centers, cable television, coffee makers, microwaves, refrigerators and Your Morning Breakfast at most locations. Create your perfect stay at any of our Comfort Inn South Carolina hotels, listed below.