Our Comfort Inn & Suites^® - Hannibal hotel is the hometown of famous author Mark Twain. While you’re here, you might enjoy seeing the spots where he grew up and was inspired to write the Adventures of Tom Sawyer. If you’re staying at our hotel for business, we offer ample business-friendly amenities to make your stay more convenient. You can use the business center with a print station and rent out our event space for large gatherings.