Our Quality Inn^® Charleston – Sikeston hotel has all the amenities you need to help you get more for your hard-earned money when you visit Charleston, MO. Located just off Interstate 55 and Interstate 57, we're convenient to Black Gold Farms and Southeast Missouri State University. Our pet-friendly hotel is also close to Interstate 24, Highway 60 and Highway 62, meaning you are within a close drive to many of the area’s best attractions. Big Oak Tree State Park and the National Quilt Museum are near the hotel. Cape Girardeau Regional Airport is a quick drive away.