Get ready for your next grand expedition with us at our Comfort Inn^® Sioux City South hotel. Many people come to the area to learn about America’s first epic road trip in Sioux City at the Lewis and Clark Interpretive Center and you can, too. Of course, we want you to rest easy knowing your accommodations are much more enjoyable than those of those early explorers. Learn about the history and culture of Sioux City with the convenience of a relaxing environment to get a great night’s rest.